multiSLIDE

multiSLIDE enables interactive visualization and exploration of quantitative single- and multi-omics datasets to reveal molecular relationships across pathways, networks, and Gene Ontologies.

Key Features:

• Interactive Heatmap Visualization: Simultaneous heatmap visualization of interconnected molecular features across one or multiple omics datasets.
• Keyword Search Functionality: Keyword-based querying that maps genes and molecular features to pathways and Gene Ontologies.
• Dynamic Data Manipulation: Rearrangement, filtering, and clustering of datasets to reorganize and refine displayed molecular features.
• Customizable Visualizations: Configurable visual output parameters to adapt heatmap displays to different omics measurement units.
• Built-in Querying Mechanisms: Multiple querying mechanisms to link molecular features at different levels of granularity across omics types.
• Integration with External Data Sources: Incorporation of inter-molecular relationships from external data sources to augment internal linkage information.

Scientific Applications:

• Systems biology and bioinformatics: Exploration of complex molecular interactions and system-level relationships within multi-omics datasets.
• Multi-omics studies: Visualization and comparison of genomics, transcriptomics, proteomics, and metabolomics measurement units and their interconnections.
• Pathway- and network-centered analysis: Analysis of pathway and network relationships to contextualize molecular feature associations.

Methodology:

Uses simultaneous heatmap visualization, keyword-based querying of pathways and Gene Ontologies, rearrangement, filtering and clustering of datasets, built-in querying mechanisms linking features at different granularities, and incorporation of external inter-molecular relationships while operating on pathways and networks for data linkage.