Mutanome

Mutanome maps somatic mutations from 10,800 tumor exomes in The Cancer Genome Atlas (TCGA) onto structure-resolved protein-protein interaction interfaces and functional sites to link genomic alterations with protein interaction perturbations and associated clinical and drug-response data.

Key Features:

• Extensive Mutation Database: Contains 490,245 mutations derived from over 10,800 tumor exomes across 33 cancer types from TCGA.
• Interaction Mapping: Maps mutations to 94,563 structure-resolved or predicted protein-protein interaction interfaces ("edgetic") and 311,022 functional sites ("nodetic"), including ligand–protein binding sites and eight types of protein posttranslational modifications.
• Clinical Correlations: Integrates survival outcomes for 8,884 cases and links 1,271,132 drug-response records to the mapped interactions.

Scientific Applications:

• Precision Medicine: Links genetic alterations to phenotypic effects and clinical outcomes to support interpretation of patient-specific variants in oncology.
• Drug Discovery and Repurposing: Uses integrated drug-response data and mutation–interaction mappings to identify actionable targets for therapeutic development or repurposing.
• Molecular Mechanism Research: Provides mapped mutation impacts on protein interactions and functional sites for studies of cancer progression and treatment response mechanisms.

Methodology:

Integrates genomic data with protein interaction networks and maps mutations to edgetic and nodetic interactions to characterize how mutations perturb biological pathways.