MyproteinNet

MyproteinNet constructs context-sensitive protein interaction networks to enable analysis of molecular pathways across organisms, human tissues, and user-defined biological conditions.

Key Features:

• Integration Across Multiple Databases: Consolidates protein–protein interaction data from up to 11 databases to build a comprehensive generic interactome.
• Context-Specific Filtering: Filters interactions by reliability scores and user-defined contexts, including molecular expression levels and protein annotations.
• Scoring of Interactions: Scores interactions for reliability to support context-specific filtering.
• Human Tissue Interactomes: Builds tissue-focused interactomes using extensive tissue expression profiles sourced from multiple resources.
• Organism and Tissue Coverage: Supports analysis across 11 organisms and numerous human tissues for comparative and tissue-specific studies.
• Output and Network Attributes: Produces output files containing generic and context-filtered interactomes along with summaries of network attributes.

Scientific Applications:

• Molecular Pathway Exploration: Enables exploration of molecular pathways active in specific conditions such as disease states or drug responses.
• Disease Mechanism Analysis: Supports identification of protein interactions relevant to disease mechanisms.
• Drug Response Analysis: Facilitates analysis of networks underlying drug responses.
• Systems Biology and Personalized Medicine: Supports hypothesis generation and testing using context-specific interactomes for systems biology and personalized medicine studies.

Methodology:

Automatically gathers and consolidates protein interaction data from multiple databases, scores interactions for reliability, and filters them according to user-defined contexts and tissue expression profiles.