mySyntenyPortal

mySyntenyPortal analyzes synteny blocks to enable large-scale comparative genomics by constructing and investigating conserved genomic regions from whole-genome sequences and user-provided synteny definitions.

Key Features:

• Custom genome input: Accepts user-provided whole-genome sequences for synteny block analysis.
• Custom synteny definitions: Supports user-supplied definitions of synteny blocks for tailored analyses.
• Multi-species synteny construction: Constructs and analyzes conserved synteny blocks among multiple species to interrogate conserved genomic regions.
• Demonstrated dataset: Applied to human, mouse, and cow genomes to identify genes potentially affected by genome rearrangements.
• Whole-genome scale: Supports large-scale whole-genome comparisons enabled by high-throughput sequencing technologies.

Scientific Applications:

• Comparative genomics: Identification and analysis of conserved genomic regions across species.
• Evolutionary biology: Inference of evolutionary relationships and genome rearrangements between species.
• Functional genomics: Investigation of genes and genomic regions potentially impacted by rearrangements for functional interpretation.
• Cross-species gene impact analysis: Identification of genes potentially affected by genome rearrangements across species such as human, mouse, and cow.

Methodology:

Constructs synteny blocks from user-provided whole-genome sequences or user-defined synteny block definitions and performs comparative whole-genome sequence analyses leveraging high-throughput sequencing data.