NanoUI

NanoUI organizes and facilitates standardized sharing and reporting of extracellular particle (EP) flow cytometry data according to the MIFlowCyt-EV framework.

Key Features:

• MIFlowCyt-EV Implementation: Implements the MIFlowCyt-EV standards to ensure rigorous reporting criteria for extracellular particle flow cytometry data.
• Genboree-based backend: Built on the Genboree software stack, the same stack used by the ClinGen Resource.
• Linked Data Hub (LDH) REST API: Uses the LDH framework implemented in Node.js for data aggregation and programmatic access.
• NanoAPI and GbAuth: Supports secure data management with NanoAPI integrated with Genboree's authentication and authorization service (GbAuth).
• ArangoDB graph database: Employs ArangoDB to represent and query complex data relationships.
• Apache Pulsar (NanoMQ) message queuing: Integrates Apache Pulsar (NanoMQ) to manage data inflows and processing.

Scientific Applications:

• Extracellular particle (EP) research: Serves as a resource for researchers investigating roles of EPs in health and disease by standardizing experimental reporting.
• Comparability and data reuse: Facilitates generation of comprehensive and comparable datasets to support cross-study analyses.
• Diagnostic and therapeutic development: Supports collaborative efforts that inform the development of diagnostic tools and therapeutic strategies involving nanoparticles.

Methodology:

Backend components include the Genboree software stack, the Linked Data Hub (LDH) REST API implemented in Node.js, NanoAPI with GbAuth for authentication and authorization, ArangoDB for graph data storage, and Apache Pulsar (NanoMQ) for message queuing.