Naview

Naview generates dynamic membrane diagrams and annotations for voltage-gated sodium channels (Nav) to visualize structural components and functional sites relevant to channel biology.

Key Features:

• Dynamic Drawing and Annotation: Constructs membrane diagrams that depict six transmembrane segments (S1-S6) across four homologous domains (D1-D4) and annotates voltage sensors, pore-lining residues, ion selectivity filters, glycosylation sites, phosphorylation sites, toxin binding sites, and inactivation loops.
• Annotation Integration: Supports incorporation of user-defined annotations and UniProt accession codes for mapping sequence- and annotation-based information onto diagrams.
• Interactive Visualization: Maps and displays residues, regions, and interrelationships using symbols, colors, and edge connections to represent structural and functional relationships.
• Publication-Ready Graphics: Produces high-quality graphics suitable for inclusion in scientific publications.

Scientific Applications:

• Structural-functional analysis: Visualizing Nav channel architecture and functional attributes including voltage sensing, pore function, and inactivation mechanisms.
• Variant interpretation and disease research: Annotating and visualizing disease-associated mutations and channelopathy-linked variants.
• Pharmacology and toxin interaction mapping: Localizing toxin binding sites and pharmacological interaction regions relevant to drug discovery and toxicology studies.
• Data integration and communication: Integrating sequence annotations (e.g., UniProt) with structural features to generate figures for publication and presentation.

Methodology:

Visualizations are implemented using the D3.js JavaScript library for operation in modern web browsers.