NBIGV-DB

NBIGV-DB organizes and characterizes immunoglobulin variable-region recombination sequences produced by non-B cells to enable comparative analysis of VHDJH and VκJκ repertoires across mouse strains, tissues, and Ig classes.

Key Features:

• Data content: 727,989 VHDJH and VκJκ recombination sequences derived from mouse samples, annotated by strain, tissue, and Ig class.
• Non-B cell scope: Includes immunoglobulins produced by epithelial cells, neurons, germ cells, and myeloid cells.
• Sequence analysis: Enables investigation of variable region sequences specific to non-B immunoglobulins and identification of conserved V(D)J patterns across non-B lineages.
• Sequence comparison: Supports sequence similarity searches using NCBI-BLAST algorithms.

Scientific Applications:

• Comparative repertoire analysis: Compare VHDJH and VκJκ repertoires across mouse strains, tissues, and Ig classes to study repertoire diversity and conservation.
• Functional inference of non-B Igs: Investigate alternative roles of non-B cell–derived immunoglobulins in cell survival, adhesion, and migration.
• Conserved V(D)J pattern discovery: Identify conserved V(D)J recombination patterns across non-B cell lineages.

Methodology:

Sequence similarity searches are performed using NCBI-BLAST algorithms.