NCIgraph

NCIgraph converts NCI Pathways Database pathway data into R graph objects to enable pathway and network analysis.

Key Features:

• Integration with NCI Pathways Database: Methods to load biological pathways from the NCI Pathways Database directly into R graph objects.
• Graph Object Representation: Converts pathways into R graph objects to enable network analyses and graph-based visualizations.
• Re-formatting Capabilities: Functionality to reformat pathway data structures for specific analytical needs or downstream applications.
• Bioconductor integration: Interoperability with the Bioconductor ecosystem to enable use with other Bioconductor packages.

Scientific Applications:

• Pathway Analysis: Exploration and analysis of curated biological pathways to investigate cellular processes and disease mechanisms.
• Network Biology Studies: Support for network biology investigations of interactions and relationships among biological components.
• Integration with genomic and statistical analyses: Combining pathway representations with genomic data and statistical methods within the R/Bioconductor environment.

Methodology:

Implemented in R and leveraging the Bioconductor ecosystem; loads NCI Pathways Database entries and converts them into R graph objects.