Non-Coding RNA database

Non-Coding RNA database catalogs comprehensive sequence and functional information on non-coding RNAs to support analysis of their roles in gene expression regulation across Eukaryotes, Eubacteria, and Archaea.

Key Features:

• Extensive Collection: Contains over 30,000 non-coding RNA sequences derived from Eukaryotes, Eubacteria, and Archaea to enable broad comparative and evolutionary analyses.
• Focused Content: Specifically excludes housekeeping transcripts, microRNAs (miRNAs), and small nucleolar RNAs (snoRNAs) to concentrate on other non-coding RNA types.
• Regulatory Roles Annotated: Documents ncRNA involvement in chromatin structure remodeling, transcriptional and translational regulation of gene expression, modulation of protein function, and control over the subcellular distribution of RNAs and proteins.
• Curation Criterion: Includes only ncRNAs that do not have protein-coding capacity.

Scientific Applications:

• Gene Expression Regulation: Enables analysis of ncRNA-mediated regulation from transcription through translation.
• Functional Studies: Supports investigation of ncRNA roles in chromatin dynamics and protein interactions.
• Comparative Genomics: Facilitates comparative and evolutionary studies of ncRNA sequences across diverse organisms.

Methodology:

Aggregates non-coding RNA sequence data and curates entries to include only ncRNAs lacking protein-coding capacity.