ncRNADrug

ncRNADrug catalogs experimentally validated and computationally predicted associations between non-coding RNAs (ncRNAs) and drugs to support studies of drug resistance mechanisms and ncRNA-targeted therapies in cancer.

Key Features:

• Extensive Data Collection: Contains 29,551 manually curated entries of ncRNA–drug resistance associations covering 266 drugs and 32,969 entries of ncRNAs targeted by 965 drugs.
• Diverse ncRNA Types: Covers microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), including 9,195 ncRNAs associated with drug resistance (2,248 miRNAs, 4,145 lncRNAs, and 2,802 circRNAs) and 10,480 ncRNAs targeted by drugs (4,338 miRNAs, 6,087 lncRNAs, and 55 circRNAs).
• Predictive Analysis: Includes computational predictions of ncRNA–drug associations derived from differential expression analysis of ncRNA profiles.
• Comprehensive Resource: Aggregates experimentally validated and predicted ncRNA–drug associations at a scale and functionality that surpass existing databases, with relevance to cancer progression and therapy.

Scientific Applications:

• Drug Development: Identifies ncRNAs involved in drug resistance to inform selection of therapeutic targets and strategies to reverse dysregulated ncRNA pathways.
• Cancer Treatment Strategies: Catalogs ncRNAs targeted by existing drugs to support exploration of combination therapies aimed at overcoming resistance.
• Research and Discovery: Facilitates investigation of ncRNA–drug interactions in molecular oncology and personalized medicine.

Methodology:

Integrates manually curated experimental data with computational predictions derived from differential expression analysis of ncRNA profiles.