ncRNAVar

ncRNAVar catalogs manually curated noncoding RNA (ncRNA) variants and their associations with human disease phenotypes to support analysis and prioritization of variant-disease relationships.

Key Features:

• Extensive association dataset: ncRNAVar compiles 4,565 associations from 2,650 publications linking 3,112 variants across 2,597 ncRNAs to 711 human disease phenotypes.
• Manual curation: Each association was reviewed by professional curators to ensure accuracy and reliability.
• Computational annotation and cross-references: The database integrates computational annotations and cross-references to external resources.
• Association scoring model: A refined scoring model assigns an association score to each entry to facilitate prioritization.

Scientific Applications:

• Biomarker discovery: Facilitate identification of ncRNA variants as diagnostic or prognostic biomarkers.
• Drug target identification: Support identification of ncRNA variants relevant to therapeutic intervention.
• Pathway analysis: Enable exploration of molecular pathways involving ncRNAs and their impact on human health.

Methodology:

Data were collected from publications, manually curated by domain experts, and computational tools were used to annotate and score associations.