NEASE

NEASE performs network enrichment analysis of alternative splicing (AS) events by integrating pathway information with structural annotations of protein-protein interactions to characterize functional impacts of AS within molecular networks.

Key Features:

• Network enrichment analysis: Performs enrichment analysis specifically tailored to alternative splicing (AS) events within interaction networks.
• Pathway and structural PPI integration: Integrates pathway information with structural annotations of protein-protein interactions to relate AS events to interaction structures.
• Functional characterization of AS: Provides functional characterization of AS events in the context of pathways and protein interaction networks.
• Tissue and development pathway identification: Identifies pathways pivotal for defining tissue identity and facilitating cell type development.
• Splicing-related biomarker highlighting: Highlights biomarkers related to alternative splicing that may be significant for disease mechanisms.
• Complementary analysis to classical pathways: Offers network-based insights that complement classical pathway analyses.

Scientific Applications:

• Functional analysis of alternative splicing: Characterizing the functional effects of AS events on pathways and protein-protein interactions.
• Tissue-specific and developmental studies: Identifying pathways and network changes that define tissue identity and cell type development.
• Biomarker discovery in disease: Highlighting splicing-related biomarkers relevant to disease pathobiology.
• Complementary pathway interpretation: Providing network-enriched interpretation to complement classical pathway analyses.

Methodology:

Integrates pathways with structural annotations of protein-protein interactions and combines pathway analysis with protein interaction networks to perform network enrichment analysis of alternative splicing (AS) events.