NeMo-TMS

NeMo-TMS enables multi-scale computational modeling of transcranial magnetic stimulation (TMS) effects on single neurons and subcellular activity.

Key Features:

• Multi-Scale Modeling Framework: Estimates induced electric fields in whole-brain volume conductor models and links macroscopic fields to microscopic neuronal effects.
• Accurate Neuron Models: Generates neuron models from morphological reconstructions and couples them to external TMS-induced electric fields for cellular and subcellular simulations.
• Simulation Capabilities: Simulates single-pulse and repetitive Transcranial Magnetic Stimulation (rTMS) protocols to probe neuronal responses under varied stimulation parameters.
• Visualization Tools: Produces 3D visualization of spatial and temporal dynamics of TMS-induced neural activity.

Scientific Applications:

• Mechanistic Studies of TMS: Dissects cellular and subcellular mechanisms by which TMS alters neuronal activity.
• Plasticity and Therapeutic Protocol Development: Supports modeling of TMS plasticity-inducing protocols to study neuroplasticity and inform therapeutic interventions for neurological disorders.
• Neural Circuit Modulation: Links field distributions to single-neuron responses to assess how TMS-induced electric fields modulate neural circuits.

Methodology:

Coupling neuron models generated from morphological reconstructions with induced electric fields computed in whole-brain volume conductor models to simulate interactions between TMS-induced fields and neuronal structures and analyze cellular and subcellular responses.