NeMO Archive

NeMO Archive curates and provides access to single-cell transcriptomic and epigenomic datasets from adult and prenatal human and mouse brains and non-human primates to support analysis of cellular diversity, development, and regulatory mechanisms generated by the BRAIN Initiative Cell Census Network and related projects.

Key Features:

• Comprehensive Data Repository: Houses transcriptomic and epigenomic datasets from over 50 million brain cells, covering major regions of adult and prenatal human and mouse brains and substantial non-human primate data as the primary repository for BICCN and related projects.
• Data FAIRness: Organized to follow Findable, Accessible, Interoperable, and Reusable (FAIR) data principles to support data discovery, integration, and reuse.
• Cloud-computing on Terra: Supports large-scale data processing and analysis on Terra (terra.bio) for cloud-based genomic workflows.
• NeMO Analytics: Provides visualization and analysis capabilities for exploration and interpretation of complex omic datasets (nemoanalytics.org).

Scientific Applications:

• Cell type mapping: Enables mapping of cellular diversity across different regions of the mammalian brain using single-cell genomic data.
• Developmental studies: Supports investigation of developmental processes from prenatal stages through adulthood.
• Comparative and evolutionary analysis: Facilitates comparison of human and non-human primate brain cell types for evolutionary and comparative studies.
• Integrative regulatory analysis: Enables combined transcriptomic and epigenomic analyses to investigate regulatory mechanisms underlying neural function and dysfunction.

Methodology:

Data are curated in collaboration with BRAIN Initiative researchers, processed at scale via Terra, and visualized/analyzed using NeMO Analytics.