NeoTCR

NeoTCR unifies publicly available neoantigen-specific TCR sequences and relevant targeted neoantigen information from experimentally-supported studies across 17 cancer subtypes to improve access to scattered data and expedite studies of neoantigen-specific TCRs and neoantigen-based immunotherapy development.

Key Features:

• Neoantigen-specific TCR Database: Contains experimentally-supported functional neoantigen-specific TCR sequences with relevant information on targeted neoantigens from studies across 17 cancer subtypes.
• TCR Clonotype Analysis: Offers annotation and visualization of TCR clonotypes from raw sequencing data.
• Neoantigen-specific TCR Discovery: Enables discovery of existing neoantigen-specific TCRs from raw sequencing data.
• Bystander TCR Exclusion: Provides exclusion of bystander virus-associated TCRs from analysis.

Scientific Applications:

• Neoantigen-based Immunotherapy Research: Expedites studies of neoantigen-specific TCRs and development of neoantigen-based immunotherapy by centralizing scattered literature data.
• TCR Repertoire Analysis: Facilitates rapid identification of neoantigen-specific TCRs from raw TCR sequencing data through integrated annotation, visualization, and database matching.
• Cancer Immunology Research: Supports investigation of TCR-mediated neoantigen recognition across 17 cancer subtypes.

Methodology:

NeoTCR was developed as an immunoinformatic database that collects and unifies neoantigen-specific TCR sequences from published literature.