NetVenn

NetVenn compares gene lists within an interactome network context to identify overlaps and contextualize them with network-based annotation, expression mapping, and power graph analyses.

Key Features:

• Interactome Network Integration: Incorporates publicly available interactome network data for multiple species and supports incorporation of customized interactome network data.
• Venn Diagram Generation: Generates Venn diagrams for comparing two to four gene lists and relates the resulting intersections to the interactome network.
• Comprehensive Gene Annotation: Annotates genes using enriched terms derived from multiple functional databases.
• Gene Expression Data Mapping: Maps gene expression data onto network nodes to indicate transcriptional status within the network context.
• Power Graph Analysis: Applies power graph analysis to simplify and summarize complex gene–gene relationship patterns within the interactome.

Scientific Applications:

• Comparative Genomics: Assess functional similarities and differences between species or experimental conditions using network-aware gene list comparisons.
• Pathway Analysis: Identify pathways implicated by overlapping or network-proximal gene sets relevant to biological processes or diseases.
• Gene Function Annotation: Enhance annotation of genes with known and predicted functions based on network interactions and enrichment terms.

Methodology:

Integrates interactome network data with Venn diagram generation, enrichment-based gene annotation, gene expression mapping, and power graph analysis.