Network of Cancer Genes

Network of Cancer Genes maps 736 cancer-related genes and 5,357 cancer-associated proteins onto a human protein-protein interaction network to enable analysis of duplicability, orthology, evolutionary appearance, and topological properties.

Key Features:

• Gene Data Integration: Compiles information on 736 cancer-related genes including duplicability, orthology, evolutionary appearance, and topological properties within a human protein-protein interaction network.
• Protein Interaction Network: Provides a detailed human protein-protein interaction network including data on primary interactors of cancer-related proteins.
• Comprehensive Protein Overview: Integrates data on 5,357 proteins involved in cancer to inform interactions and pathways related to oncogenesis.
• Dynamic Resource: Continuously updated with new findings from mutational screenings of cancer genomes.

Scientific Applications:

• Gene Analysis: Retrieves detailed information on specific cancer genes for targeted studies and hypothesis generation.
• Comparative Studies: Identifies common properties among precompiled lists of cancer genes for comparative genomics and evolutionary biology research.
• Protein Interaction Research: Supports investigations into molecular mechanisms of cancer development through protein interaction data.

Methodology:

Systematically gathers and integrates genetic and proteomic data from existing databases and mutational screening results to build a human protein-protein interaction network reflecting direct and indirect protein relationships, with advanced bioinformatics techniques applied to ensure data accuracy and relevance.