NG-Circos

NG-Circos renders interactive JavaScript-based Circos-style circular visualizations of multi-dimensional next-generation genomic data to facilitate interpretation of genomic rearrangements, structural variations, comparative genomics, gene expression patterns, and multi-omics integration.

Key Features:

• Interactive visualization: Provides interactive Circos-style plots that enable dynamic exploration of genomic relationships and patterns.
• Modular design: Comprises 21 functional modules that can be combined to represent different genomic and omics data types.
• Support for diverse data types: Processes and visualizes a wide range of genomic and multi-dimensional datasets for integrated representation.

Scientific Applications:

• Genomic rearrangements and structural variation visualization: Visualizes structural variants and rearrangements within a circular genome context.
• Comparative genomics: Represents synteny and inter-chromosomal relationships for comparative analyses.
• Gene expression pattern exploration: Displays gene expression changes across conditions or time points in a circular layout.
• Multi-dimensional data integration: Integrates multiple genomic and omics datasets into a single cohesive circular visualization.

Methodology:

Implements a flexible JavaScript-based framework that constructs interactive Circos plots by integrating 21 functional modules to process and visualize various genomic data types.