NIAGADS

NIAGADS maintains a national data repository for human genetics research on Alzheimer's disease and related dementias, providing qualified researchers with access to genetics and genomics data including whole genome and exome sequence data, genotype/phenotype data, and genome-wide association summary statistics with biological annotations.

Key Features:

• Data Repository: Houses genetics and genomics data for Alzheimer's disease, related dementias, and healthy aging, encompassing 211,000 samples.
• Controlled Data Access: Shares data with research groups via the Data Sharing Service, a Federal Information Security Modernization Act moderate compliant cloud-based platform supporting the National Institutes of Health Genomic Data Sharing Policy.
• Open Access Knowledge Bases: Provides multiple knowledge bases with genome-wide association summary statistics and rich annotations on the biological significance of genetic variants and genes across the human genome.
• Alzheimer's Disease Sequencing Project Dataset: Hosts the largest Alzheimer's disease and related dementias joint called whole genome sequencing dataset with approximately 58,000 whole genomes.

Scientific Applications:

• Alzheimer's Disease Genetics Research: Supports genetics data production and analysis for investigating the genetic basis of Alzheimer's disease and related dementias.
• Genomic Variant Interpretation: Enables exploration of biological significance of genetic variants and genes through annotated open access data resources.
• Collaborative Research: Facilitates data sharing with hundreds of research groups worldwide to advance understanding and treatment of Alzheimer's disease.

Methodology:

NIAGADS supports genetics data production and analysis including whole genome and exome sequencing data processing, with data stored and distributed through a cloud-based platform compliant with Federal Information Security Modernization Act moderate standards.