NoD

NoD predicts nucleolar localization sequences (NoLSs) in proteins, short basic motifs that direct proteins to the nucleolus, a nuclear sub-compartment responsible for ribosomal RNA synthesis and ribosome assembly.

Key Features:

• Prediction of NoLSs: Predicts nucleolar localization sequences (NoLSs) in protein sequences.
• Taxonomic scope: Provides predictions across diverse eukaryotes and viruses.
• Human proteome coverage: Identified predicted NoLSs in 9,531 out of 43,534 human proteins from IPI version 3.40.

Scientific Applications:

• Protein localization mapping: Enables identification of sequences that target proteins to the nucleolus for studies of subnuclear localization.
• Functional and disease studies: Supports investigation of functional roles of nucleolar proteins and potential links to cellular biology and disease mechanisms.

Methodology:

Computational prediction of NoLSs from protein sequences.