NPCARE

NPCARE consolidates verified data on natural products and fractional extracts with experimentally validated anticancer activities to support research into cancer gene regulation.

Key Features:

• Extensive Data Collection: Contains 6,578 natural compounds and 2,566 fractional extracts derived from plants, marine organisms, fungi, and bacteria covering 1,952 distinct species.
• Cancer Type Specificity: Annotates each entry with the specific cancer type affected.
• Biological Source Information: Provides genus and species annotations for each biological source.
• Cell Line Validation: Includes validation data from 1,107 cell lines across 34 cancer types.
• Target Gene/Protein Information: Provides annotations of target genes and proteins associated with anticancer activities.
• Diverse Biological Resources: Includes 743 plant genera and 197 plant families among its documented sources.
• Curation and Verification: Entries include experimentally verified anticancer activity evidence.

Scientific Applications:

• Anticancer Drug Discovery: Supports identification and prioritization of natural compounds and fractional extracts as therapeutic leads.
• Mechanistic Studies: Enables investigation of molecular mechanisms via annotated target genes and proteins.
• Cell-Line Specific Selection: Facilitates selection of compounds validated in particular cell lines across 34 cancer types.
• Biodiversity-Guided Exploration: Enables exploration of compounds from plants, marine organisms, fungi, and bacteria for cancer research.

Methodology:

Entries were curated and validated using experimentally verified anticancer activity data across multiple cell lines and cancer types.