NucEnvDB

NucEnvDB catalogs nuclear envelope (NE) proteins and their protein–protein interactions to support analyses of NE localization, chromatin tethering, genome organization, nucleocytoplasmic exchange, and regulation of signaling pathways in eukaryotic cells.

Key Features:

• Comprehensive NE protein repository: Catalogs nuclear envelope proteins and their documented interactions relevant to eukaryotic cell biology.
• Localization annotation: Records specific localizations of proteins within the nuclear envelope.
• Interaction documentation: Documents protein–protein interactions among NE proteins and their partners.
• Cross-references: Provides cross-references from entries to major biological databases.
• Protein–protein interaction network construction: Constructs and visualizes protein–protein interaction networks to reveal NE interaction patterns.
• Functional enrichment analysis: Performs functional enrichment analysis to identify biological processes associated with NE protein clusters and interactors.

Scientific Applications:

• Disease mechanism analysis (Hutchinson-Gilford progeria syndrome): Enables investigation of protein–protein interactions implicated in Hutchinson-Gilford progeria syndrome.
• Viral interaction studies (SARS-CoV-2): Supports analysis of the impact of SARS-CoV-2 infection on NE proteins and nuclear envelope dynamics.
• NE functional studies: Facilitates studies of chromatin tethering, genome organization, nucleocytoplasmic exchange, and regulation of signaling pathways at the nuclear envelope.

Methodology:

Curated database entries with annotations and cross-references to major biological databases, construction and visualization of protein–protein interaction networks, and functional enrichment analysis.