oRNAment

oRNAment maps putative RNA-binding protein (RBP) target motifs across complete transcriptomes of human, Caenorhabditis elegans, Danio rerio (zebrafish), Drosophila melanogaster (fruit fly), and Mus musculus (mouse) to support analysis of RNA–protein interactions in messenger RNAs and non-coding RNAs.

Key Features:

• Comprehensive mapping: Over 421 billion putative RBP binding site instances mapped across five species.
• RBP and motif coverage: Includes data for 223 RBPs and 453 consensus target motifs.
• Transcriptome coverage: Contains mappings for 525,718 complete coding and non-coding RNA species.
• Species coverage: Covers human, Caenorhabditis elegans, Danio rerio (zebrafish), Drosophila melanogaster (fruit fly), and Mus musculus (mouse).
• Motif provenance: Consensus motifs derived from in vitro selection assays such as RNAcompete and RNA Bind-n-Seq.
• Transcriptome-wide instances: Provides transcriptome-wide localization of motif occurrences mapped to transcripts.

Scientific Applications:

• RNA metabolism studies: Enables analysis of RBP motif distributions relevant to RNA synthesis, processing, trafficking, stability, and degradation.
• RNA–protein interaction research: Supports basic research on RNA–protein interactions by supplying putative motif occurrence data.
• Gene regulation and disease studies: Facilitates applied investigations into gene regulation and mechanisms of disease involving RBPs.

Methodology:

Integrates consensus target motifs defined by in vitro selection methods (RNAcompete, RNA Bind-n-Seq) and maps putative motif instances across complete transcriptomes.