OBI

OBI automates large-scale analysis and systematization of positive selection in proteins to support comparative and structural evolutionary studies.

Key Features:

• Automation and Efficiency: Automates workflows for large-scale positive selection analysis across many protein families.
• Customization and Flexibility: Provides multiple starting points and configurable analysis options to tailor studies to specific research needs.
• Integration with Phylogenomics Pipelines: Integrates into phylogenomics pipelines to support large-scale comparative analyses.
• Data Retrieval and Linkage: Retrieves and links structural and evolutionary protein data to enable combined analyses of evolution and structure-function relationships.

Scientific Applications:

• Vaccine design: Identifies protein sites under positive selection relevant to antigenic variation and vaccine target selection.
• Detection of variants of circulating drug-resistant pathogens: Facilitates analysis of variants by identifying evolutionary pressures on pathogen proteins.
• Protein evolutionary and structural analyses: Enables large-scale studies of evolutionary pressures on proteins linked to structural data.

Methodology:

Automates data-processing steps and integrates structural and evolutionary datasets with configurable starting points for positive selection analysis.