ODORactor

ODORactor predicts odorant receptors (ORs) activated by small molecules from their molecular structures and supports browsing of curated OR–ligand pairs.

Key Features:

• Structure-based OR prediction: Predicts ORs from arbitrary chemical structures, indicating candidate receptor activation by specific odorants.
• Odorant verification: Performs odorant verification to evaluate chemical structures for odorant properties.
• OR recognition: Maps odorants to candidate ORs through OR recognition based on molecular structure.
• Curated OR–ligand database: Provides a comprehensive repertoire of OR–ligand interactions curated from the literature for browsing and reference.
• Experimental validation: Incorporates experimentally validated OR responses for various odorants to support and corroborate predictions.

Scientific Applications:

• Olfactory coding studies: Deciphering complex olfactory coding mechanisms by linking odorants to their candidate ORs.
• Basic olfactory research: Investigating the molecular basis of smell and receptor–ligand specificity.
• Odorant discovery: Supporting discovery and characterization of novel odorants through predicted OR interactions.
• Fragrance and flavor development: Guiding design and selection of fragrance or flavor compounds via predicted OR–ligand relationships.

Methodology:

Performs odorant verification and OR recognition to predict OR activation from molecular structures and supplies a literature-curated OR–ligand database.