OGP

OGP compiles a curated repository of site-specific O-glycosylation data and a predictive resource to support analysis of protein O-glycosylation in biological and clinical research.

Key Features:

• Extensive Data Collection: OGP aggregates 9,354 O-glycosylation sites and 11,633 site-specific O-glycans mapped to 2,133 distinct O-glycoproteins from diverse published studies.
• O-Glycosylation Site Prediction Tool: OGP includes a predictive tool that uses recorded O-glycosites to identify potential glycosylation sites.
• Comprehensive Molecular Annotations: OGP provides protein accession numbers, glycopeptide sequences, site-specific glycan structures, and experimental method annotations for recorded entries.

Scientific Applications:

• Cancer Research: Facilitates analysis of glycosylation patterns associated with cancer progression and metastasis.
• Biopharmaceutical Development: Supports design and optimization of biologics through characterization of O-glycan modifications.
• Clinical Trials: Enables profiling of therapeutic protein glycosylation to assess efficacy and safety.

Methodology:

Records were curated from diverse published studies; entries include mapped O-glycosylation sites and site-specific O-glycans (9,354 sites, 11,633 glycans, 2,133 proteins), and a site-prediction tool was built using the recorded O-glycosites.