OGT-PIN

OGT-PIN catalogs experimentally identified protein interactors of O-linked N-acetylglucosamine transferase (OGT) and its orthologues across multiple species to support analysis of OGT-centered molecular networks.

Key Features:

• Extensive Curation: Datasets were rigorously curated from public repositories and specialized publications focused on O-GlcNAc modifications to ensure high-confidence interactions.
• Broad Species Coverage: Includes interactome data from Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, and Arabidopsis thaliana.
• High-Stringency Interactors: Identifies up to 929 high-stringency OGT interactors, including 784 proteins annotated as human OGT interactors.
• Functional Diversity: Encompasses proteins involved in DNA repair, RNA metabolism, translational regulation, and cell cycle control, with enrichment in regulators of transcription and (co)translation.
• Hub Protein Insight: The compiled dataset indicates that OGT functions as a hub protein within cellular molecular networks.

Scientific Applications:

• Cell Biology: Facilitates analysis of OGT-mediated protein interactions underlying cellular processes such as transcription, translation, and cell cycle control.
• Molecular Genetics: Supports investigation of genetic and molecular regulation associated with OGT and O-GlcNAcylation.
• Disease Research: Enables exploration of associations between OGT interaction networks and diseases, particularly those involving dysregulation of transcription and translation.

Methodology:

Datasets were curated from public repositories and specialized publications on O-GlcNAc modifications and filtered using high-stringency criteria to identify OGT interactors.