OMAMO

OMAMO identifies optimal model organisms for studying specific human biological processes by leveraging conservation of pathways and orthologous genes across species and is implemented in JAVA.

Key Features:

• Orthologous Relationship Analysis: OMAMO utilizes a comprehensive database of orthologous genes and pathways to determine which non-human species share significant genetic similarities with humans for specific biological processes.
• Systematic Literature Review Support: OMAMO's recommendations are supported by systematic literature reviews that back suggested model organism choices.
• Comprehensive Database: The database includes a wide range of species, expanding options beyond traditional models such as mice, rats, and zebrafish.

Scientific Applications:

• Model organism selection for human biological processes: OMAMO supports selection of optimal model organisms for studying specific human biological processes by analyzing gene and pathway conservation.
• Identification of simpler alternative model organisms: OMAMO enables identification of simpler, less complex organisms that can serve as alternatives to traditional models such as mice, rats, and zebrafish.
• Comparative conservation analysis: OMAMO facilitates comparative analysis of pathway and gene conservation across species to inform model choice.

Methodology:

Analyzes orthologous relationships using a comprehensive database of orthologous genes and pathways to assess conservation of genes and pathways across species; recommendations are backed by systematic literature reviews; implemented in JAVA.