OMIA

OMIA catalogs inherited disorders, single-locus traits, and associated genes across 233 animal species (excluding humans, mice, rats, and species with dedicated resources) to support comparative genetics and veterinary genomics.

Key Features:

• Curated and annotated catalogue: Contains manually curated entries of inherited disorders, single-locus traits, and associated genes across 233 non-model animal species.
• Phenotype–genotype linkage: Relates phenotypic descriptions of heritable traits to corresponding genetic components where available.
• OMIM-based structure: Adopts a structured entry format modeled after Online Mendelian Inheritance in Man (OMIM) to standardize descriptions of traits and genes.
• Database infrastructure: Implements a MySQL platform for data management hosted by the Australian National Genomic Information Service (ANGIS).
• Integration with genomic resources: Links and integrates information with existing genomic databases to contextualize genetic data.
• Collaborative curation: Accepts contributions from species- and disorder-specific researchers to update and refine annotations.

Scientific Applications:

• Comparative genomics: Enables cross-species comparison of genes and traits to identify conserved and divergent genetic factors.
• Evolutionary biology: Supports analyses of the evolution of heritable traits and genetic variation across diverse animal lineages.
• Veterinary genetics: Provides a reference for inherited disorders and trait-associated genes relevant to veterinary diagnosis and research.
• Animal breeding and conservation: Informs breeding programs and conservation genetics by documenting trait heritability and associated loci.

Methodology:

Data are stored in and managed via a MySQL database hosted by the Australian National Genomic Information Service (ANGIS).