OmicCircos

OmicCircos generates high-quality circular plots to visualize complex genomic variations, including mutation patterns, copy number variations (CNVs), gene expression, and DNA methylation within the R/Bioconductor environment.

Key Features:

• Circular plot generation: Produces layered circular plots for genome-wide visualization of omics data.
• Multiple plot types: Supports scatterplots, line graphs, and text-label figures to display mutation, CNV, expression, and methylation data.
• Link visualization: Uses polygons and curves, including link-polygons, to illustrate relationships among genomic features across chromosome positions.
• Independent track drawing: Enables independent drawing and integration of multiple data tracks within the circular layout.
• Position-independent heatmaps: Supports heatmaps that are not constrained by chromosomal coordinates.
• Summary plots: Generates cluster plots, boxplots, histograms, and heatmaps for data summarization and interpretation.
• Zoom functions: Provides zooming capabilities to explore specific genomic regions in greater detail.
• R/Bioconductor integration: Leverages R/Bioconductor statistical and graphic functions for analysis and visualization.

Scientific Applications:

• Genomic variation visualization: Visualizes mutation patterns, CNVs, gene expression, and DNA methylation across genomes.
• Inter-chromosomal relationship mapping: Maps relationships among genomic features across chromosome positions using polygons and curves.
• Multi-omics integration: Integrates multiple omics data types within a single circular framework for comparative visualization.
• Statistical result presentation: Presents results of statistical analyses using cluster plots, boxplots, histograms, and heatmaps.

Methodology:

Generates circular plots and layered tracks using R/Bioconductor graphic and statistical functions to draw scatterplots, line plots, text labels, polygons/curves (link-polygons), position-independent heatmaps, and standard summary plots, and supports zooming.