omicsPrint

omicsPrint verifies sample identity and genetic relationships by comparing genotype calls from SNP arrays and DNA- and RNA-based sequencing and by inferring genotypes from Illumina DNA methylation array data to detect sample swaps, labeling errors, and first-degree familial relationships.

Key Features:

• Input data support: Accepts genotype calls from SNP arrays and DNA- and RNA-based sequencing and infers genotypes from Illumina DNA methylation array data.
• Classification-based linkage verification: Uses a classification approach to confirm sample linkages and detect discrepancies arising from handling or labeling errors.
• Familial relationship detection: Identifies first-degree familial relationships, including parent–offspring connections and twin zygosity, when sufficient genotype data are available.
• Output formats: Produces graphical and textual outputs for inspection of linkage results.

Scientific Applications:

• Sample identity verification: Confirms concordance of samples across SNP arrays, sequencing platforms, and methylation-derived genotypes.
• Sample swap and label-error detection: Detects mismatches indicative of handling or labeling errors.
• Familial relationship validation: Validates parent–offspring relationships and other first-degree links.
• Twin zygosity assessment: Assesses zygosity in twin studies using available genotype data.

Methodology:

OmicsPrint employs a classification approach to confirm sample linkages and identify discrepancies arising from handling or labeling errors.