OmicsTIDE

OmicsTIDE compares trends across multi-omics datasets to identify concordant and discordant regulatory patterns and support interpretation of biological information transfer and phenotype manifestation.

Key Features:

• Trend comparison: Visualizes trends across different omics layers to assess concordance and discordance of regulatory patterns.
• Automated clustering and trend analysis: Performs automated clustering of omics data to identify and segregate regulatory trends.
• Profile plots and Sankey diagrams: Represents identified trends with profile plots and connects trends across datasets using Sankey diagrams for pairwise comparisons.
• Classification framework: Applies a classification framework that categorizes omics data based on data type and experimental design.
• Scalability: Scales to large-scale and high-throughput transcriptome and other omics datasets.

Scientific Applications:

• Cross-layer regulatory analysis: Elucidates relationships between different biological layers and their collective impact on phenotypes.
• Hypothesis generation and validation: Supports generation and validation of hypotheses across diverse experimental designs.
• High-throughput omics studies: Applicable to large-scale transcriptome analyses and other omics-based research.

Methodology:

Initial automated clustering of omics data to determine trends, followed by visualization of trends using profile plots and Sankey diagrams.