OncoCardioDB

OncoCardioDB aggregates curated molecular data from 83 systematically reviewed papers (up to 2021) to characterize genes, genetic variations, and drug–disease relationships linking cancer and cardiovascular diseases for research use.

Key Features:

• Curated Molecular Data: Aggregates and organizes validated molecular information—genes, variations, drugs, and study metadata—extracted from 83 systematically reviewed papers up to 2021.
• Standardized Nomenclature: Applies standard nomenclature for genes, pathologies, and other entities to ensure consistency and interoperability.
• Flexible Query System: Provides a flexible query system supporting simplified and complex queries to explore molecular connections between cancer and cardiovascular diseases.
• Dynamic Updates: Regularly updated and refined as new studies become available.

Scientific Applications:

• Hypothesis Generation: Enables exploration of potential molecular connections between oncology and cardiology to generate testable hypotheses.
• Drug Repurposing: Facilitates examination of drug–gene interactions to identify potential new therapeutic uses for existing drugs.
• Personalized Medicine: Highlights genetic variations relevant to individual patient conditions to inform tailored treatment strategies.

Methodology:

Compiled via a systematic literature search to curate information from relevant studies; entities are modeled as objects for structured organization and efficient querying.