OncoSearch

OncoSearch identifies and aggregates reported gene expression changes from biomedical literature to support analysis of genes involved in oncogenesis.

Key Features:

• Targeted Query Capability: Supports specification of up-regulated or down-regulated expression for queried genes, enabling directional analysis of gene roles.
• Cancer Progression and Regression Analysis: Correlates reported gene expression changes with progression or regression of specific cancer types.
• Role Specification: Enables querying of expected functional roles of genes in the context of cancer based on literature evidence.

Scientific Applications:

• Oncogenesis research: Aggregates and analyzes evidence from Medline abstracts to study how specific genes contribute to cancer development or suppression.
• Biomarker identification: Aids identification of potential diagnostic, prognostic, or therapeutic biomarker candidates based on reported expression patterns.
• Evidence retrieval and curation: Provides targeted retrieval of sentences reporting gene expression changes in cancer to support literature-based evidence compilation.

Methodology:

Applies text-mining to Medline abstracts and other biomedical literature to extract sentences that describe gene expression changes in the context of cancer, compiles and aggregates the extracted information, and supports filters for expression directionality (up or down) and association with progression or regression.