ONIX

ONIX integrates multimodal neural recording and perturbation during naturalistic behavior through a unified open-source data acquisition system with high data throughput and low closed-loop latency.

Key Features:

• High-throughput data acquisition: ONIX achieves data throughput of 2 GB s-1 with closed-loop latencies below 1 ms.
• Minimal behavioral impact tethering: A 0.3-mm thin tether minimizes behavioral impact during freely moving recordings.
• Active commutation: Three-dimensional head position and rotation tracking drives active commutation without torque measurements.
• Multimodal device compatibility: ONIX acquires data from passive electrodes, Neuropixels probes, head-mounted microscopes, cameras, three-dimensional trackers, and other data sources.
• Long-duration recording capability: The system enables uninterrupted recordings of approximately 7 hours during complex three-dimensional terrain traversal and multiday sleep-tracking recordings of approximately 55 hours.

Scientific Applications:

• Freely behaving neural recording: ONIX enables long-duration recordings from large neural populations during unimpeded animal behavior in freely moving conditions.
• Three-dimensional behavioral neuroscience: The system supports exploration with similar mobility as nonimplanted animals during complex three-dimensional terrain traversal.
• Multiday sleep tracking: ONIX enables continuous multiday neural recordings during sleep states.
• Closed-loop perturbation: The low-latency architecture supports closed-loop neural perturbation experiments.

Methodology:

ONIX uses a 0.3-mm thin tether for data transmission, implements three-dimensional head position and rotation tracking to drive active commutation without torque measurements, and integrates multiple data streams through a unified acquisition architecture.