Open PHACTS Explorer

Open PHACTS Explorer provides integrated access to pharmacological data using semantic web standards and technologies to support data-driven drug discovery.

Key Features:

• Public-Private Partnership: Collaboration among academia, publishers, small and medium-sized enterprises, and pharmaceutical companies aggregates diverse public and proprietary data sources.
• Semantic Web Technologies: Uses semantic web standards and technologies to enhance data interoperability and integrate disparate datasets into an open pharmacological space.
• Practical Applications: Supports workflows that address specific drug discovery challenges by leveraging integrated pharmacological data for analysis.
• Open Innovation Support: Enables open innovation while accommodating non-public, in-house pharmaceutical research initiatives.

Scientific Applications:

• Integrative pharmacology queries: Enables answering pharmacology questions by integrating multiple heterogeneous data sources.
• Target identification and validation: Facilitates target identification and validation using aggregated pharmacological and related data.
• Lead optimization: Supports lead optimization by providing integrated datasets relevant to compound selection and evaluation.
• Preclinical testing: Facilitates preclinical decision-making through access to consolidated pharmacological information.

Methodology:

Enhances and applies semantic web standards and technologies to integrate datasets and create a unified open pharmacological space for data sharing and interoperability.