OpenCMISS

OpenCMISS implements finite element analysis to integrate and solve partial differential equations for multi-scale biophysical and physiological models.

Key Features:

• Model Encoding Standards: Uses CellML and FieldML for model representation and interoperability.
• Partial Differential Equation Solvers: Integrates and solves PDEs arising in biophysical models using finite element methods.
• Multi-Scale Modelling: Links subcellular processes with tissue- and organ-level dynamics to enable coupled multi-scale simulations.
• Distributed Memory Architecture: Employs a distributed memory computational architecture to support large-scale simulations.
• Coupling of Physical Equations: Couples diverse equation sets such as myocardial wall mechanics with ventricular and coronary flow and reaction-diffusion equations with ion channel current models.
• Flexible Infrastructure: Provides interfaces for linking physical equations across common boundaries or spatial fields to combine models from different projects.

Scientific Applications:

• Cardiac mechanics and electrophysiology: Enables detailed simulations integrating myocardial deformation, ventricular and coronary flow, and electrical propagation via reaction-diffusion and ion channel models.
• Physiome / Virtual Physiological Human modelling: Supports integrative physiological and biomedical research through standardized model representation and multi-physics coupling.

Methodology:

Finite element analysis to integrate and solve PDEs; model encoding with CellML and FieldML; distributed memory parallel computation; coupling of reaction-diffusion equations and ion channel current models with mechanical and flow equations.