OpenMandible

OpenMandible generates simulation-ready, multiscale numerical models of lower mandible physiology using cone beam computerized tomography (CBCT) and micro-computed tomography (μCT) for biomechanical simulation.

Key Features:

• Imaging integration: Integrates cone beam computerized tomography (CBCT) and micro-computed tomography (μCT) to produce multiscale mandibular models.
• Anatomical detail: Represents spongy and compact bone, 14 teeth with dentin, enamel, periodontal ligament, and pulp, simplified temporomandibular joints, and masticatory muscles including masseter, temporalis, medial, and lateral pterygoid.
• Mesh generation: Produces simulation-ready meshes using tet4 and hex8 elements.
• C++ implementation: Provides a C++ software component that generates the simulation-ready models.
• Orthotropic cortical bone modeling: Incorporates orthotropic micromechanical characteristics of cortical bone via a geodesic wave propagation-based approach.
• Muscle modeling algorithm: Models muscles as uniformly directed vectors to represent masticatory force directions.
• Boundary conditions: Supports application of Neumann and Dirichlet boundary conditions.
• Virtual treatment and disease scenarios: Enables simulation of tooth restoration, implant placement, and mandible bone degradation by modifying the baseline model.

Scientific Applications:

• Tooth restoration: Simulates restorative procedures and their biomechanical effects on the mandible and dentition.
• Implant placement: Evaluates biomechanical outcomes of dental implant scenarios within a multiscale mandibular model.
• Mandible bone degradation: Models bone loss and disease effects on mandibular mechanics.
• Medical device development: Assesses device interactions and mechanical performance in mandibular simulations.
• Jaw mechanics and masticatory function: Studies biomechanical behavior of the mandible and masticatory muscles.
• Craniofacial and dental research: Provides a multiscale platform for mandibular physiology research in dental and craniofacial studies.

Methodology:

Integration of cone beam computerized tomography (CBCT) and micro-computed tomography (μCT) data; construction of multiscale anatomical representations including spongy and compact bone and dental tissues; mesh generation with tet4 and hex8 elements; assignment of orthotropic cortical bone properties via a geodesic wave propagation-based approach; muscle representation as uniformly directed vectors; and application of Neumann and Dirichlet boundary conditions.