OPTICS

OPTICS provides a comprehensive database of optogenetic systems (OSs) with detailed biophysical properties, functional data, and photoreceptor-based classification to facilitate the design of optogenetic controls.

Key Features:

• Photoreceptor-based classification: OPTICS systematically describes diverse optogenetic systems from the perspective of photoreceptor-based classification and mechanism of action.
• Biophysical and functional data: OPTICS features detailed biophysical properties and functional data of optogenetic systems.
• Optogenetic tool and cellular protein interaction mapping: OPTICS provides the interaction between optogenetic tools and cellular bio-functional proteins for each optogenetic system referring to distinct applications in research, diagnosis, and therapy.
• Light response property-based search: OPTICS enables a light response property-based search against all optogenetic systems in the database.

Scientific Applications:

• Optogenetic control design: OPTICS supports rapid and predictable design of optogenetic controls through comprehensive data on optogenetic systems.
• Novel optogenetic system development: The comprehensive data in OPTICS lays a foundation for future development of novel optogenetic systems.
• Research, diagnosis, and therapy: OPTICS documents distinct applications of optogenetic tool and cellular protein interactions across research, diagnosis, and therapy contexts.

Methodology:

OPTICS employs photoreceptor-based classification and mechanism of action analysis to organize optogenetic systems, with data curated to capture biophysical properties, functional characteristics, and light response properties of photosensory and bio-functional proteins.