OriDB

OriDB catalogs curated DNA replication origin sites and associated origin-mapping data for Saccharomyces cerevisiae and Schizosaccharomyces pombe to support studies of replication initiation.

Key Features:

• Curated Data Sets: Compiles origin mapping studies and applies source validation to provide high-quality datasets of replication origins.
• Species Coverage: Contains replication origin data for Saccharomyces cerevisiae and Schizosaccharomyces pombe to enable comparative analyses between these model yeasts.

Scientific Applications:

• Comparative Genomics: Enables comparison of replication origin sites between Saccharomyces cerevisiae and Schizosaccharomyces pombe to investigate evolutionary conservation and divergence of replication initiation.
• Functional Genomics: Correlates replication origins with gene expression patterns and chromatin structure to infer functional roles of specific genomic regions.
• Biotechnological Applications: Provides origin site information relevant to synthetic biology and other applications requiring precise control of DNA replication.

Methodology:

Collates data from genome-wide origin-mapping studies that identify and confirm replication origins.