OrthoInspector

OrthoInspector identifies orthologous and inparalogous relationships among genes across species to support comparative genomics, protein family analysis, and functional annotation.

Key Features:

• Original algorithm: Uses an original algorithm specifically tailored to detect orthology and inparalogy, enabling rapid and accurate relationship predictions.
• Proteome-scale analysis: Processes input proteomes and supports analysis of very large databases accommodating thousands of proteomes.
• Sequence similarity and phylogenetic integration: Infers relationships by leveraging sequence similarity together with phylogenetic information.
• Visualization tools: Integrates visualization capabilities for comparative genomics and protein family analysis.
• Precomputed orthology databases: Provides three online databases of precomputed orthology relationships.

Scientific Applications:

• Comparative Genomics: Compare genomes across species to study evolutionary processes and gene conservation.
• Protein Family Analysis: Identify and analyze protein families to infer evolutionary history and functional roles.
• Functional Annotation: Predict orthologs to transfer functional annotations from model organisms.

Methodology:

Applies the original algorithm to process input proteomes and identify orthologous and inparalogous relationships by leveraging sequence similarity and phylogenetic information, and is implemented to handle large-scale proteome databases.