The Osprey Network Visualization System

The Osprey Network Visualization System visualizes and enables analysis and manipulation of complex biological interaction networks for examination of physical and genetic interactions.

Key Features:

• Data-Rich Graphical Representations: Generates detailed, color-coded graphical representations that annotate nodes and edges by gene function and experimental interaction data.
• Spoke Model Format: Employs a spoke model format for network diagrams to represent and expand interactions between a central bait and multiple preys.
• Integration with Large-Scale Datasets: Supports user-defined large-scale datasets for incorporation of external experimental data and comparison across methods.

Scientific Applications:

• Genomics: Visualizes and analyzes genetic interaction networks to identify gene function and interaction patterns.
• Proteomics: Maps physical protein–protein interaction networks and annotates experimental interaction data for proteome-scale studies.
• Systems Biology: Integrates and represents large-scale interaction networks to assist in elucidating mechanisms underlying biological processes.

Methodology:

Uses graphical network representations with color-coding by gene function and experimental interaction data and a spoke model format for network diagrams.