ovirustdb

ovirustdb aggregates curated experimental and annotation data on therapeutically relevant oncolytic viruses to support research in oncolytic virus-based immunotherapy.

Key Features:

• Database size and schema: 5,927 records documented across 25 fields providing structured annotations for each entry.
• Virus taxonomy: Contains data for nine types of DNA viruses and fifteen types of RNA viruses.
• Strain classification: Includes 300 recombinant strains and nine wild-type viral strains.
• Cancer and cell-line coverage: Records report testing against 124 cancer types and 427 cancer cell lines.
• Combination therapy data: 1,047 records document improved anti-cancer responses when oncolytic viruses are combined with anti-cancer drugs.
• Mechanisms of action: 3,243 records document induction of apoptosis and 1,506 records report immune activation as mechanisms of cancer cell death.

Scientific Applications:

• Oncolytic virus design and discovery: Provides virus-specific annotations and interaction data to inform engineering and selection of candidate oncolytic viruses.
• Evaluation of combination therapies: Enables analysis of synergistic effects between oncolytic viruses and anti-cancer drugs using 1,047 combination records.
• Mechanism-of-action studies: Supports investigation of apoptosis and immune-activation pathways using records documenting these outcomes.
• Preclinical model selection: Informs selection of cancer types and cell lines for experimental validation based on coverage of 124 cancer types and 427 cell lines.

Methodology:

Curated repository compiling and annotating experimental records (5,927 entries) across 25 descriptive fields.