oxdbase

oxdbase catalogs biodegradative oxygenases (E.C. Class 1), including monooxygenases and dioxygenases that oxidize substrates using molecular oxygen (O2) with co-substrates FAD, NADH, or NADPH, to support study of oxygenase-mediated metabolism of organic compounds.

Key Features:

• Literature-curated dataset: Contains a compilation of over 235 oxygenases curated from primary literature.
• Dual search engines: Provides separate search/indexing facilities for monooxygenases and dioxygenases to enable targeted retrieval.
• Detailed enzyme entries: Records include common names and synonyms, the specific reaction catalyzed, family and subfamily classification, structural details, gene links, and literature citations.
• Integration with external databases: Entries are cross-referenced with BRENDA, KEGG, ENZYME, and UM-BBD.

Scientific Applications:

• Metabolism studies: Enables analysis of oxygenase roles in the metabolism and biodegradation of organic compounds and studies of oxidoreductases (E.C. Class 1).
• Synthetic chemistry: Provides enzyme-specific reaction and classification information useful for researchers in synthetic chemistry.
• Bioremediation: Supports identification of biodegradative oxygenases relevant to bioremediation of organic pollutants.

Methodology:

Entries were compiled from primary literature and linked to external databases BRENDA, KEGG, ENZYME, and UM-BBD, with separate indexing/search facilities for monooxygenases and dioxygenases.