PanelPRO

PanelPRO: Multi-gene, multi-cancer germline mutation risk modeling

PanelPRO implements multi-syndrome, multi-gene cancer risk prediction using pedigree data to estimate probabilities of germline mutations across an extended panel of cancer susceptibility genes by integrating family histories of multiple cancers.

Key Features:

• Multi-gene, Multi-cancer Modeling: Estimates mutation carrier probabilities across multiple genes and cancer types within a unified framework.
• Pedigree-based Bayesian Framework: Incorporates family history data and published parameter estimates to compute individualized risk predictions.
• Customizable Gene-Cancer Panels: Allows selection of arbitrary combinations of genes and cancers with modifiable model parameters.
• Integration of BayesMendel Models: Extends established single-syndrome models including BRCAPRO and MMRPRO within a unified multi-syndrome framework.

Scientific Applications:

• Hereditary Cancer Risk Assessment: Quantifies probabilities of inherited germline mutations to support genetic risk stratification and preventive decision-making.

Methodology:

PanelPRO applies a Bayesian Mendelian modeling approach to pedigree data, integrating published penetrance, prevalence, and genotype-phenotype association parameters to jointly model multiple cancer syndromes and estimate posterior probabilities of germline mutations across selected gene panels.