PAT

PAT identifies structured units within protein sequences to define optimized domain boundaries and detect putative non-domain folded regions for biochemical studies and synthetic antibody target selection.

Key Features:

• Domain Identification: Locates structural domains within protein sequences and optimizes their boundaries for improved accuracy.
• Non-Domain Structured Units: Detects putative structured units that do not conform to traditional domain definitions.
• Structural Property Analysis: Analyzes structural properties and evaluates folding stability to characterize potential secondary and tertiary structures.
• Performance Superiority: Defines reliable domain boundaries and characterizes structurally well-defined regions with higher accuracy than existing methods.

Scientific Applications:

• Antibody Target Identification: Identifies soluble and well-defined secondary and tertiary structures as candidate targets for synthetic antibody generation.
• Experimental Validation: Has identified experimentally confirmed antibody targets, supporting its applicability in experimental workflows.

Methodology:

Integrates analytical approaches to assess structural properties and folding stability and provides pre-calculated results for 20,210 human proteins.