Pathema

Pathema provides curated genomic databases and integrated analysis for NIAID Category A–C pathogens to support comparative genomics and research on six priority organisms: Bacillus anthracis, Clostridium botulinum, Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens, and Entamoeba histolytica.

Key Features:

• Clade-specific databases: Four clade-specific web resources and databases organized to meet data and analysis needs for distinct pathogen clades.
• Comprehensive genome collection: Includes all publicly available complete genome projects of phylogenetically related organisms for comparative study.
• Integrated analysis tools: Integration with web-based analysis tools to obtain, display, and compute results relevant to pathogen genomics.
• Inter-genomic comparisons: Supports comparative analyses across related organisms to facilitate genomic exploration.
• Data dissemination for research: Disseminates genomic data to support bio-defense and infectious disease research communities.

Scientific Applications:

• Pathogen research: Enables study of genomic features of NIAID Category A–C pathogens including Bacillus anthracis, Clostridium botulinum, Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens, and Entamoeba histolytica.
• Comparative genomics: Facilitates inter-genomic comparisons to identify phylogenetic relationships and conserved or unique genomic elements.
• Detection, diagnosis, and treatment research: Supports research aimed at understanding, detecting, diagnosing, and treating priority infectious agents relevant to bio-defense.

Methodology:

Integrates publicly available complete genome projects and performs inter-genomic comparisons by obtaining, displaying, and computing results via web-based analysis tools.