Pathway Miner

Pathway Miner maps gene sets to metabolic, cellular, and regulatory pathways and extracts gene product association networks to support pathway-centric analysis and statistical ranking.

Key Features:

• Pathway Cataloging: Catalogs genes by their involvement in metabolic, cellular, and regulatory networks to reveal functional pathway membership.
• Gene Mapping and Network Extraction: Maps input genes onto relevant pathways and extracts gene product association networks for genes that co-occur within those pathways.
• Statistical Analysis with Fisher Exact Test: Applies the Fisher exact test to rank pathways by statistical significance for given gene sets.
• Customizable Network Filtering: Filters extracted networks based on selected criteria to refine analyses of pathway-associated gene interactions.

Scientific Applications:

• Genomics and systems biology: Supports studies that require characterization of gene interactions and organization within known biological pathways.
• Hypothesis generation and target identification: Aids data interpretation, hypothesis generation, and identification of potential therapeutic targets from pathway-level analyses.

Methodology:

Integrates gene expression data with pathway databases, extracts gene product association networks for co-occurring genes, and applies the Fisher exact test to rank pathways.