Patrocles

Patrocles catalogs and analyzes miRNA-related genetic variants to assess their impacts on miRNA-mediated gene regulation across seven vertebrate species.

Key Features:

• Species coverage: Contains curated data for seven vertebrate species to enable comparative analyses of miRNA-related variants.
• Comprehensive compartments analysis: Reports variants affecting miRNA targets, miRNA precursors, and components of the silencing machinery.
• Contextual data and visualization: Provides contextual information including graphical representations of miRNA–target coexpression patterns and expression Quantitative Trait Loci (eQTL) effects on target genes by genotype.
• Copy number variants and eQTL integration: Integrates Copy Number Variants (CNVs) and eQTL data that influence miRNA precursors and genes encoding silencing machinery components.
• Patrocles Finder: Evaluates whether specific DSPs may affect miRNA-mediated regulation in user-provided target sequences.

Scientific Applications:

• Disease and trait genetics: Identification of DSPs that alter miRNA–target interactions or silencing machinery genes to study genetic contributions to disease and trait variation.
• Variant prioritization: Prioritization of candidate regulatory variants based on coexpression and eQTL contextual evidence.
• Evolutionary analysis: Investigation of selective pressures on miRNA target sites and related variants to study evolutionary maintenance of miRNA–target integrity.

Methodology:

Includes analyses for signatures of selection on "Patrocles single nucleotide polymorphisms (pSNPs)" in human and mouse genomes.