PBIL

PBIL provides access to EMBL, GenBank, SWISS-PROT, and PIR and integrates ACNUC-based querying with similarity searches, multiple sequence alignment, protein structure prediction, and multivariate statistical analyses for retrieval and analysis of nucleotide and protein sequences.

Key Features:

• Access to Sequence Databanks: Direct access to EMBL and GenBank for nucleotide sequences and SWISS-PROT and PIR for protein sequences.
• Advanced Query Capabilities: ACNUC-based complex queries that target functional zones and retrieve extensive sequence sets, with specialized PBIL tools for gene family interrogation.
• Integration of Retrieval and Analysis: Seamless integration of sequence retrieval and downstream analysis using re-usable lists to enable batch processing and treatment of large sequence datasets.
• Diverse Analytical Tools: Provision of similarity search programs, multiple alignment tools, protein structure prediction methods, and multivariate statistical analyses for sequence and structural interpretation.

Scientific Applications:

• Genomics: Retrieval and comparative analysis of nucleotide sequences from EMBL and GenBank for genomic studies and gene-family investigation.
• Proteomics: Use of SWISS-PROT and PIR data combined with similarity searches and protein structure prediction for protein-level analyses.
• Molecular Biology: Functional studies of gene families and high-throughput sequence analyses enabled by ACNUC queries and batch processing with re-usable lists.

Methodology:

ACNUC-based complex queries; access to EMBL, GenBank, SWISS-PROT, and PIR; creation and use of re-usable lists for batch processing; similarity searches; multiple sequence alignment; protein structure prediction methods; multivariate statistical analyses.